http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2008007416-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_88fbcd2a70a3c49d0aed69a000d55909 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 |
| filingDate | 2006-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_551e15e2a48d0012c41049a6d6206839 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_96f9bd6339b14bd7983c327459143d68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc54331e16a719493604f5086bad3a5a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0c94b2e6304b3cb3233d4e66b4845c9b |
| publicationDate | 2008-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2008007416-A |
| titleOfInvention | N-substituted aniline derivatives, 1-substituted indole derivatives, 1- (1-pyridin-2-ylmethyl-piperidin-4-yl) -1H-indole and 3- (1-methyl-1H-indol-3-yl)- Process for producing 4- [1- [1- (pyridin-2-ylmethyl) piperidin-4-yl] -1H-indol-3-yl] -1H-pyrrole-2,5-dione |
| abstract | 【Task】 Intermediate 1- (1-pyridin-2-ylmethyl-piperidin-4-yl) -1H-indole, which is important for producing enzastaurine useful as an anticancer agent, is inexpensively and efficiently produced in high yield To provide a manufacturing method capable of And a method for producing enzastaurine using the compound. [Solution] A method for producing a 1-substituted indole derivative in which a reductive amination reaction between an aniline derivative and a carbonyl compound is performed using hydrogen, followed by a cyclization reaction, and 1- (1 using the method for producing a 1-substituted indole derivative -Method for producing pyridin-2-ylmethyl-piperidin-4-yl) -1H-indole and enzastaurine. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2009035537-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9951038-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014102588-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9963458-B2 |
| priorityDate | 2006-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 97.