| abstract |
A novel compound that inhibits the activity of poly (ADP-ribose) polymerase (generally referred to as PARP), and a pharmaceutical composition containing the compound. A phthalazinone derivative of formula (I) and a pharmaceutical composition containing the compound. (Wherein A and B together represent a fused aromatic ring, X can be NR X or CR X R Y, and when X = NR X , n is 1 or 2; When X = CR X R Y , n is 1, R X is selected from H, C 1-20 alkyl, C 5-20 aryl, C 3-20 heterocyclyl, amide, etc., and R Y is H , Hydroxy, amino, and R 1 is selected from H and halo) [Selection figure] None |