abstract |
The present invention provides a modified recombinant virus with improved safety and a method for producing such a recombinant virus. A modified recombinant virus is produced, wherein the gene function encoded by the virus is inactivated, thereby reducing the toxicity and increasing the safety. Its gene function is non-essential and associated with toxicity. The virus is advantageously a poxvirus, in particular a vaccinia virus or an avipox virus. This modified recombinant virus contains an antigen or epitope and / or a CTL epitope derived from an immunodeficiency virus, such as HIV1 gag (+ pro) (IIIB), gp120 (MN) (+ transmembrane) in a non-essential region of the viral genome. ), Nef (BRU) CTL, pol (IIIB) CTL, ELDKWA, LDKW epitopes and the like. [Selection figure] None |