| abstract |
The use of WRN modulators is described. WRN activators can be used to induce growth arrest, apoptosis, or proliferative senescence. On the other hand, inhibitors of WRN can be used to reduce growth arrest, apoptosis, or proliferative aging. A method for identifying modulators of WRN is also described. In this application, a method for screening for modulators of WRN is provided. The method comprises (a) providing a cell that expresses WRN; (b) contacting a candidate modulator with the cell under conditions that allow the modulator to be taken up by the cell; and (c) DNA. Measuring a property of the cell associated with activation of a damage response pathway; a change in the property compared to a control indicates a modulator of WRN. |