| abstract |
The present invention relates to methods and means for producing humanized antibodies from transgenic non-human animals. The present invention specifically relates to novel immunoglobulin heavy and immunoglobulin light chain constructs, recombinant and transgenic vectors, transgenics useful in generating transgenic non-human animals that express humanized antibodies. It relates to animals, as well as humanized immunoglobulin preparations. In one aspect, the invention relates to an isolated nucleic acid molecule comprising a human immunoglobulin gene segment flanked by multiple nucleotide sequences. |