| abstract |
The present invention relates to asthma and chronic obstructive pulmonary disease containing fibroblast growth factor-2 (FGF2) or basic fibroblast growth factor (bFGF) as an active ingredient. (Chronic Obstructive Pulmonary Disease, COPD). The present invention also relates to Th1 asthma and COPD mouse animal models induced by ovalbumin (Ovalbumin, OA) and double-stranded RNA (dsRNA). The therapeutic agent containing FGF2 as an active ingredient according to the present invention can be usefully used for treating or preventing airway fibrosis, airway inflammation, airway hypersensitivity, airway remodeling, asthma and COPD. In addition, asthma and COPD animal models developed using egg albumin and double-stranded RNA can be usefully used for the development of asthma and COPD therapeutic agents. |