abstract |
Hydroxy-substituted pyrazinopyrrolopyridazinedione compounds are inhibitors of HIV integrase and inhibitors of HIV replication. In certain embodiments, the dione compound has the formula (I) (Wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are defined herein). The compounds are useful in the prevention and treatment of HIV-induced infection, AIDS prevention, onset delay and treatment. The compound is used against HIV infection and AIDS as the compound itself or in the form of a pharmaceutically acceptable salt. The compounds and their salts can be used as ingredients in pharmaceutical compositions, optionally in combination with other antiviral agents, immunomodulators, antibiotics or vaccines. |