| abstract |
The present invention provides a novel amide derivative that has a matrix metalloprotease inhibitory action and is useful as a pharmaceutical. The derivative is formula [Wherein, A ring is an optionally substituted nitrogen-containing heterocyclic ring, and B ring is an optionally substituted monocyclic homocyclic ring or an optionally substituted monocyclic heterocyclic ring, Z is N or NR 1 (R 1 is a hydrocarbon group which may optionally be a hydrogen atom or a substituent.), - - - is a single bond or a double bond, R 2 is hydrogen atom or a substituent An optionally substituted hydrocarbon group, X is an optionally substituted spacer having 1 to 6 atoms, and ring C is (1) an optionally substituted homocyclic ring or (2) (X ′ is S, O, SO or CH 2 ), which is a heterocyclic ring which may be substituted other than the ring represented by the formula, and at least one of the B ring and the C ring has a substituent. However, N-{(1S, 2R) -1- (3,5-difluorobenzyl) -3-[(3-ethylbenzyl) amino] -2-hydroxypropyl} -5,6-dimethyl-4-oxo- Excludes 1,4-dihydrothieno [2,3-d] pyrimidine-2-carboxamide. Or a salt thereof. [Selection figure] None |