| abstract |
A chemokine receptor activity modulator, with certain inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic symptoms (including allergic rhinitis, dermatitis, conjunctivitis, and asthma) and autoimmune diseases (eg rheumatoid arthritis, Formula I useful for the prevention or treatment of atherosclerosis): Wherein n, R 1 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 15 , R 16 , Y and Z are as defined in the specification. Compound). The present invention further relates to pharmaceutical compositions containing these compounds and the use of these compounds and compositions in the prevention or treatment of the aforementioned diseases involving chemokine receptors. |