http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2007533718-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D273-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D245-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D267-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D273-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K36-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-167 |
| filingDate | 2005-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2007-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2007533718-A |
| titleOfInvention | Benzoxazocines and their therapeutic use as monoamine reuptake inhibitors |
| abstract | Compounds having therapeutic utility may be of the general formula (1), wherein R 1 is H, C 1 -C 6 alkyl, optionally substituted with F or C 3 -C 6 cycloalkyl. Or A 2 is C 2 -C 4 alkenyl; A is O, CH 2 or S (O) n , wherein n is 0-2; within W, X, Y and Z One is N, CH or CR 3 and the other is CH; R 2 is C 5 -C 6 heteroaryl, C 5 -C 10 cycloalkyl or cycloalkenyl, wherein O, N and S (O) n which may contain one or more heteroatoms selected from n (wherein n is 0 to 2) and optionally substituted with R 3 ; or a phenyl group In one or more positions, halogen, CN CF 3, C 1 -C 6 alkyl and are those which may be optionally substituted with one or more substituents independently selected from OR 1, or the phenyl group, carbocyclic, heterocyclic Cyclic (containing 1-2 heteroatoms selected from O, N and S), aromatic or heteroaromatic (containing 1-2 heteroatoms selected from O and N) Is fused to an optional 5- or 6-membered ring; R 3 is halogen; CF 3 ; CN; OR 5 ; SO 2 N (R 5 ) 2 ; COR 5 ; CO 2 R 5 ; CON (R 5) 2; NR 1 COR 4 ; NR 1 SO 2 R 4; NR 1 CO 2 R 4; NR 1 CON (R 5) 2; OC substituted with R 3 1 -C 6 alkyl; unsubstituted R 3 or C 1 -C which are optionally substituted in Alkyl; when in the unsubstituted R 3; when is C 3 -C 6 may have a cycloalkyl substituted by at unsubstituted R 3; if it C 2 -C 6 alkenyl substituted by at unsubstituted R 3 C 2 -C 6 alkynyl optionally substituted by: aryl optionally substituted with unsubstituted R 3 ; and 5-membered or 6 containing 1-4 heteroatoms selected from N and O Selected from membered aromatic heterocycles; R 4 is C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 6 cycloalkyl, aryl and heteroaryl; And R 5 is H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 6 cycloalkyl, aryl or heteroaryl and The same as or different from another R 5 ]; or a pharmaceutically acceptable salt thereof. [Selection figure] None |
| priorityDate | 2004-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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