| abstract |
The compounds of the present invention have the structure described by Formula I or a salt or hydrate form thereof. (Where X is S or SO 2 ; R 1 is (1C-6C) alkyl, (3C-6C) alkenyl or (3C-6C) alkynyl ((3C-6C) cycloalkyl, OH, OC, respectively. (O) (1C-4C) alkyl, (1C-4C) alkoxy, halogen, cyano, formyl, C (O) (1C-4C) alkyl, CO 2 H or CO 2 (1C-4C) alkyl, C (O ) NR 5 R 6 , optionally substituted with S (O) (1C-4C) alkyl or S (O) 2 (1C-4C) alkyl.); R 2 is hydrogen, (1C-4C ) Alkyl or C (O) (1C-4C) alkyl; R 3 is (1C-4C) alkyl, (1C-4C) fluoroalkyl, (1C-4C) alkoxy, (1C-4C) fluoroalkoxy, halogen Optionally cyano or nitro substituted phenyl group; or, R 3 is, (1C-4C) alkyl, (1C-4C) fluoroalkyl, (1C-4C) alkoxy, needs halogen or cyano An optionally substituted 5- or 6-membered aromatic heterocyclic ring structure; R 4 is, in the ortho position, 1-hydroxy (1C-4C) alkyl, (1C-4C) alkoxy, C (O) (1C-4C) alkyl, CO 2 (1C-4C) alkyl, C (O) NH 2, cyano, nitro or CH = NOR 7, and (1C-2C) alkyl, (1C-2C) fluoroalkyl or was further optionally substituted with halogen, phenyl group or an aromatic 6-membered heterocyclic ring; R 5 is, (1C-2C) alkyl, (1C-2C) full Be Roarukiru or by 2-pyridyl optionally substituted with halogen; or, R 5 and R 6 are independently hydrogen or (1C-4C) alkyl; R 7 is hydrogen or C (O) (1C-4C) alkyl; R 8 , R 9 , R 10 are independently hydrogen, (1C-2C) alkyl, fluoro or chloro. ) |