| abstract |
The present invention is useful in the treatment of graft rejection and / or in the treatment of certain inflammatory diseases, which are unexpectedly desirable pharmacological properties, in particular highly active immunosuppressive agents. As such, a group of tri- and tetra-substituted pteridine derivatives, their pharmacologically acceptable salts, N-oxides, solvates, dihydro- and tetrahydro-derivatives and enantiomers. These compounds are also useful in preventing or treating cardiovascular diseases, allergic conditions, central nervous system diseases and cell proliferation diseases. |