| abstract |
The present invention discloses novel depeptideized compounds having HCV protease inhibitory activity, as well as compositions containing such compounds, and methods of using them to treat disorders associated with HCV protease. In many embodiments, the invention provides a novel class of inhibitors of HCV protease, pharmaceutical compositions containing one or more compounds, methods of preparing pharmaceutical formulations containing one or more such compounds, And a method of treating or preventing HCV using one or more such compounds or one or more such formulations or a method of ameliorating one or more symptoms of hepatitis C. Also provided are methods for modulating the interaction between HCV polypeptides and HCV protease. Of the compounds provided herein, compounds that inhibit HCV NS3 / NS4a serine protease activity are preferred. |