| abstract |
The present invention relates to novel compounds useful as melanocortin receptor modulators. In particular, the present invention relates to a compound WS727713, a method for producing the compound by culturing a WS727713-producing strain belonging to Pseudonocardia in a culture medium and recovering the compound from the culture broth, a pharmaceutical composition containing the compound, melanocortin, Use of the compounds for the manufacture of drugs or cosmetics for receptor modulation, ischemia / reperfusion injury, inflammatory diseases of the brain and kidneys, hepatitis, septic / septic shock, hypoxic shock Acute respiratory distress syndrome (ARDS), rheumatoid arthritis (RA), gouty arthritis, aortic regurgitation (AR), juvenile chronic arthritis, osteoarthritis, nephritis, tolerance induction, contact hypersensitivity, inflammatory bowel Disease (IBD), sexual dysfunction, transplantation, pain, exacerbation of HIV disease, post-inflammation depigmentation, folding screen, idiopathic drip hypomelanosis, fever, functional bowel disease, obesity, satiety effect, diabetes, Regulation of skin exocrine function, gray hair (Localized gray hair), gray hair, pancreatitis, fibrosis (hypertrophic scar, keloid, localized scleroderma, systemic sclerosis, scleroderma skin graft versus host rejection, cirrhosis, Treatment of idiopathic bleomycin-induced pulmonary fibrosis, cyclosporine-induced nephropathy), uveitis (especially in Behcet's syndrome and sarcoidosis), vasculitis, microbial infection, celiac disease, vulvar vestibular syndrome, melanoma infiltration, anorexia Or the use of the compound for the manufacture of a medicament for prevention or cosmetics. [Selection figure] None |