| abstract |
Formula (I) [wherein R 1 is an organic group having at least 8 atoms selected from C or O, and the organic group is directly bonded to N via —C (O) —. And includes at least one aromatic ring], and pharmaceutical compositions thereof. These compounds are selective GSK-3 inhibitors and have improved bioavailability. They are useful for the treatment of GSK-3 mediated diseases, especially Alzheimer's disease, type II diabetes, depression and brain damage. |