| abstract |
The present invention relates to novel substituted 5-membered ring compounds and their pharmaceutically acceptable salts, esters or prodrugs, compositions of pharmaceutically acceptable carriers and new compounds, and uses of the new compounds. . The compounds of the present invention have the following general formula (I): Also provided is a pharmaceutical composition comprising a compound of formula I and a pharmaceutically acceptable excipient or carrier. In one embodiment, the disorder mediated at least in part by CDC7, PKA and / or Akt is a cell proliferative disorder. The cell proliferative disorder can be cancer. In another aspect, the cancer can be a tumor or neoplasm selected from the group consisting of carcinoma, adenoma and sarcoma. |