| abstract |
The present invention relates to methods and products for inducing IL-10 expression using immunostimulatory nucleic acids. In particular, the present invention relates to methods and products for inducing IL-10 expression without inducing high levels of IFN-α expression. The IL-10-induced immunostimulatory nucleic acid preferably comprises a TC dinucleotide at the 5 'end and a CG dinucleotide at the 3' end that is not near the 5 'end. The present invention is suitable for treating and preventing diseases associated with Th1 or Th2 immune responses, or for suppressing inappropriate immune responses (eg, for regulating or suppressing excessive immune responses). Useful for promoting the environment of regulatory T cells. |