| abstract |
Pharmaceutical compositions and dosage forms containing an adsorbent and an adverse agent, such as an opioid antagonist. In one embodiment, at least a portion of the adverse agent is present on the surface of the adsorbent material or within the microporous structure. Pharmaceutical compositions and dosage forms containing an adsorbent and an adverse agent are useful for preventing or preventing misuse, abuse, misuse or diversion of dosage forms containing an active agent, such as an opioid. is there. The present invention also relates to a kit comprising a method for treating a patient with such a dosage form, and instructions indicating how to use such dosage form and the dosage form for treating a patient. The invention further relates to methods for producing such pharmaceutical compositions and dosage forms. [Selection] Figure 1 |