| abstract |
A neutralizing epitope is identified within amino acids 40-64 of mature human myostatin. Antibodies that bind to this epitope are within the scope of the invention and may be murine, chimeric or humanized antibodies, immune complexes of antibodies, or antigen-binding fragments thereof. The antibodies of the present invention are useful for the treatment of increased muscle mass, increased bone density, or various disorders in mammals. |