| abstract |
(R) -2- [4- (trifluoromethanesulfonyloxy) phenyl] propionamide derivatives of the formula (I) (provided that the variables are as defined in the claims) and such compounds The pharmaceutical composition is useful for inhibiting chemotactic activation of neutrophils (PMN leukocytes) induced by the interaction of interleukin-8 (IL-8) with CXCR1 and CXCR2 membrane receptors . The compounds are used for the prevention and treatment of pathologies resulting from said activation. In particular, these metabolites have no cyclo-oxygenase inhibitory activity and depend on neutrophil dependent pathologies such as psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bullous pemphigoid It is particularly useful for the treatment of rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and the prevention and treatment of damage caused by ischemia and reperfusion. |