| abstract |
A foamed formulation comprising multi-layer foamed microspheres containing desmopressin, preferably containing an acidic substance, a basic substance and a water-soluble separating agent. Most foamed formulations containing desmopressin foam immediately upon dissolution of the multilayer foamed microspheres in water, and then become a solution or homogeneous dispersion of desmopressin. The preparation is used for the treatment of diabetes insipidus, nocturnal urine, postoperative polyuria or polydipsia, nocturnal urinary illness associated with multiple sclerosis, mild to moderate hemophilia or von Willebrand disease . |