| abstract |
The present invention provides a compound of formula (I) 4-{[1- (aminocarbonyl) -4-piperidinyl] amino} -N-[(3,4-dimethylphenyl) methyl] -1-ethyl-1H-pyrazolo [3,4-b ] Pyridine-5-carboxamide or a salt thereof is provided. The present invention also relates to the inhibition of phosphodiesterase type IV (PDE4) of said compounds or pharmaceutically acceptable salts thereof in the treatment and / or prevention of eg inflammatory and / or allergic diseases, cognitive disorders or depression in mammals. Provide use as an agent. In particular, the present invention provides the use of said compounds or pharmaceutically acceptable salts thereof in the treatment and / or prevention of mammalian atopic dermatitis, for example by external topical administration to mammals (eg humans). To do. Also provided are pharmaceutical compositions containing the compounds or salts, particularly those suitable for external topical administration. [Selection figure] None |