| abstract |
[Chemical 1] The present invention relates to novel arylpiperidine or piperazine compounds substituted with certain 5-membered heterocycles having apoB secretion / MTP inhibitory activity and concomitant lipid lowering activity. The invention further relates to such compounds, to a process for the preparation of a pharmaceutical composition comprising said compounds, and to the use of said compounds as medicaments for the treatment of hyperlipidemia, obesity and type II diabetes (formula ( I)). The invention further provides such compounds, methods for the preparation of pharmaceutical compositions comprising said compounds, and atherosclerosis, pancreatitis, obesity, hypertriglyceridemia, hypercholesterolemia, hyperlipidemia, diabetes and II. The use of said compound as a medicament for the treatment of type 2 diabetes. |