| abstract |
Ability to promote angiogenesis when impaired bone marrow cells are introduced into ischemic sites in patients by transfecting early-adherent cells derived from bone marrow in culture with pro-angiogenic transgenes Provide a method for enhancing In order to deliver a pro-angiogenic transgene or protein to a patient, such early-adherent cells derived from autologous bone marrow or cells (which need not be from autologous cells) are cultured. Also provided is a method for utilizing media derived from these cells when grown in Transfected early adherent cells, or media derived from these cells when grown in culture, are introduced into ischemic tissues such as the heart to enhance the formation of collateral blood vessels. The Cells or media can also be infused into the bloodstream (arteries that are the supply path to ischemic tissue, or any other artery or vein). |