| abstract |
Provided are compounds that act as one or more potent modulators of CCR1, CCR2 and CCR3 receptors. The compounds are generally fused nitrogen heterocycles, spiro nitrogen heterocycles or bridged nitrogen heterocycles having aryl and heteroaryl components, and pharmaceutical compositions for the treatment of CCR1, CCR2 and / or CCR3-mediated diseases Useful as a control in assays for the identification of competitive receptor antagonists for the chemokine receptors. |