| abstract |
Disclosed is a family of novel protein constructs that are useful as drugs and for other purposes, termed “adzymes”, which contain an address portion and a catalytic domain. Preferred adzymes are those that have a mesotrypsin based catalytic domain (including functional fragments, derivatives, variants, homologues, and / or stabilized mutations thereof). Another preferred adzyme is one having a targeting moiety based on a protein scaffold, such a protein having an immunoglobulin-like fold. |