abstract |
The present invention provides a mammary gland-specific transcriptional control region whose genome is operably linked to i) a cDNA encoding a rotavirus protein selected from VP2, VP4, VP6 and VP7, comprising a secretory signal sequence. A first transgene, and ii) at least a second transduction comprising a mammary gland specific transcriptional control region operably linked to a cDNA encoding another rotavirus protein comprising a secretory signal sequence The present invention relates to a transgenic non-human mammal containing a gene, wherein the rotavirus protein is secreted separately in milk, where it becomes a rotavirus-like particle (VLP) or an aggregate of the rotavirus protein. Self-assemble. |