| abstract |
An isolated human monoclonal antibody that binds to anthrax infection protective antigen 035 is disclosed. Human antibodies can be produced in non-human transgenic animals, such as transgenic mice, that are capable of producing multiple isotypes of human monoclonal antibodies by undergoing VDJ recombination and isotype switching. Also, derivatives of human antibodies (eg, bispecific antibodies and immune complexes), pharmaceutical compositions comprising human antibodies, non-human transgenic animals and hybridomas producing human antibodies, and treatment using human antibodies And diagnostic methods are also disclosed. |