| abstract |
Alkyl linked nucleotide compositions and nucleotide affinity media containing alkyl linked nucleotides are provided. The linker is generally a hydrophobic linker, which can be 3, 4, 5, 6, 7, 8, 9, 10, or longer carbon chains. The invention also includes methods for synthesizing alkyl-linked nucleotides, nucleotide affinity media, and methods for using them in affinity chromatography and screening methods. |