| abstract |
A dual-functional compound, an inhibitor of an enzyme that is catechol-O-methyltransferase (COMT), and a partial agonist or antagonist of D2 receptor, or an agonist of D1 receptor, or Provides a compound that interacts with both D1 and D2 receptors. It also describes the use of the present compounds to treat neuropsychiatric disorders, particularly schizophrenia and mild cognitive impairment. |