| abstract |
The present invention allows a user to identify inhibitors of tissue granulation within and around the wound, thereby limiting excessive scar formation associated with healing of the damaged tissue. Some of the granulation inhibitors identified using the method of the present invention inhibit granulation in and around the wound site by up to a factor of 5, and when tested for retinal damage, correspondingly produce scar tissue formation. Decrease. Granulation inhibitors that can be identified using the methods of the present invention include antibodies, peptides, nucleic acids (aptamers) and non-peptide low molecular weight molecules. |