| abstract |
The present invention relates to tetrahydro-quinolinyl urea derivatives and salts thereof useful as active ingredients in pharmaceutical preparations. The tetrahydro-quinolinyl urea derivatives of the present invention have vanilloid receptor (VR1) antagonist activity and prevent and treat diseases associated with VR1 activity, particularly urological diseases or disorders such as detrusor hypersensitivity (overactive bladder), Urinary incontinence, neurogenic detrusor hypersensitivity (detrusor hyperreflexia), idiopathic detrusor hypersensitivity (detrusor instability), benign prostatic hypertrophy, and lower urinary tract symptoms; chronic pain, neuropathic pain, postoperative pain, It can be used to treat rheumatoid arthritis, neuralgia, neuropathy, hyperalgesia, nerve injury, ischemia, neurodegeneration, stroke, and inflammatory disorders such as asthma and chronic obstructive pulmonary (or airway) disease (COPD). |