| abstract |
The present invention relates to certain substituted N-phenyl-piperazine derivatives of formula (I), which are modulators of the 5HT 2C receptor. Accordingly, the compounds of the present invention are useful for the prevention or treatment of diseases or disorders associated with the 5HT 2C receptor (eg, obesity, Alzheimer's disease, erectile dysfunction and related disorders). Another aspect of the invention relates to a pharmaceutical composition comprising a pharmaceutically acceptable carrier in combination with at least one compound according to formula (I). Another aspect of the invention relates to a method of modulating a 5HT 2C receptor, the method comprising contacting the receptor with a therapeutically effective amount or a therapeutically effective dose of a compound as described herein. Includes. Another aspect of the invention relates to a method of preventing or treating central nervous system disorders: damage to the central nervous system; cardiovascular disorders; gastrointestinal disorders; diabetes insipidus or sleep apnea. |