http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2007523095-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D475-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D475-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-525 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-06 |
| filingDate | 2005-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2007-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2007523095-A |
| titleOfInvention | Process for producing crystalline (6RS) -N (5) -formyl-5,6,7,8-tetrahydrofolic acid |
| abstract | The crystalline (6RS) -N (5) -formyl-5,6,7,8-tetrahydrofolic acid or amorphous (6S) -N (5) -formyl-5,6,7,8- Tetrahydrofolic acid is prepared by adding an aqueous solution of (6RS)-or (6S) -calcium formate at a temperature of 40 ° C to 50 ° C and an aqueous solution of hydrochloric acid or acetic acid to stirred water at a temperature of 2 ° C to 12 ° C. However, in the mixture obtained during the addition of both solutions, the temperature is kept at a value between 2 ° C. and 12 ° C. on the one hand and the pH value is kept at a value between 2.5 and 3.5 on the other hand. And the solid formed is isolated by filtration or centrifugation, this solid is first washed with cold water and then with an aqueous organic solvent, and the washed solid, ie crystalline (6RS) -N (5) -Formyl-5,6,7,8-tetrahydrofolic acid Amorphous (6S) -N (5) - wherein the obtained formyl-5,6,7,8-tetrahydrofolic acid and dried under reduced pressure. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2012197275-A |
| priorityDate | 2004-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 60.