| abstract |
The present invention relates to a method of isolating cells using a signaling probe that generates a signal upon hybridization to a target sequence, or creating a cell line. Other methods that utilize signaling probes include quantifying the level of RNA expression, identifying genetic recombination events in living cells, and generating transgenic animals using isolated cells. A method is mentioned. The present invention also provides a protease probe. Signaling probes and protease probes that form stem-loop structures, three-arm junction structures, and dumbbell structures are provided. |