| abstract |
The present invention relates to compositions and methods for tissue regeneration, particularly for treating skin damage, eg, wounds. In one aspect, the present invention provides a wound treatment composition comprising cells, such as fibroblasts, living within a support matrix, such as fibrin, wherein the cells have a wound treatment phenotype. And the composition is monolayered and provides a wound treatment composition that has been incubated for up to about 8 days to allow development of the wound treatment phenotype. The compositions and methods of the present invention are particularly useful in assisting in the healing process of wound healing, specifically chronic open wounds that are slow or resistant to healing. |