| abstract |
In certain embodiments, providing compositions and methods for increasing drug efficiency. In certain embodiments, conjugates are provided for compositions and methods in the treatment of various diseases, wherein Formula 1: DLS (1) or Formula 2: DLS '( 2) wherein D is a drug component, L is a non-releasable linker component that may or may not be present, and S is a substrate for a kinase other than hexokinase, protein kinase, or lipid kinase And S ′ is a substrate for phosphotransferases other than hexokinase, protein kinase, or lipid kinase). |