| abstract |
The present invention relates to substituted benzazepines (not peptides) of formula (I) useful as vasopressin receptor antagonists for treating diseases associated with vasopressin receptor activity, such as those associated with increased vascular resistance. In particular, heart failure (including congestive heart failure), hyponatremia and hypertension are disclosed herein. In addition, a pharmaceutical composition containing a compound represented by formula (I) and hypertension, congestive heart failure, heart failure, coronary vasospasm, cardiac ischemia, cirrhosis, hyponatremia, renal vasospasm, renal failure, diabetes Also disclosed are methods of treating diseases such as nephropathy, cerebral edema, cerebral ischemia, stroke, thrombosis or stasis. |