| abstract |
The present application provides methods and compositions for inhibiting demyelination, promoting remyelination, and / or treating paralysis in a subject in need thereof. Preferably, such compositions, when administered in effective amounts, inhibit immunoglobulin demyelination and / or promote remyelination in an immunoglobulin (eg, antibody, antibody fragment and recombinant). Antibodies or fragments produced), polypeptides (eg, soluble forms of ligand proteins for integrins) and small molecules. The compositions and methods described herein can also utilize other anti-inflammatory agents used to alleviate conditions and diseases associated with demyelination. |