| abstract |
Use of a CCR3 antagonist of formula (I) or a pharmaceutically acceptable salt thereof for the treatment of asthma, and novel compounds of formula (II), pharmaceutical compositions comprising them, and their use in the treatment of asthma Use is disclosed, wherein R, R a , X, X a , R 1 , R 2 , R 2a , R 14 , R 14a , R 16 and n are as defined in the specification. The present invention relates to the use of piperidine derivatives as selective CCR3 antagonists for the treatment of asthma. The present invention also relates to a class of novel compounds useful as selective CCR3 antagonists, pharmaceutical compositions comprising the novel compounds, and methods of treatment using the novel compounds. Additional novel compounds having CCR3 antagonist activity are also claimed. |