| abstract |
Formula I (Wherein the dashed lines, R 1 , R 2 , R 3a , R 3b , A, D, E, G and L have the meanings given herein). Which are useful as competitive inhibitors of trypsin-like proteases such as thrombin or as prodrugs of the inhibitors, and in particular, inhibition of thrombin is beneficial Useful in the treatment of conditions (eg, conditions such as thromboembolism where thrombin inhibition is or is desired, and / or conditions where anticoagulant therapy is required). |