| abstract |
The invention includes, for example, hypertension, depression, generalized anxiety disorder, phobias, post-traumatic stress disorder, avoidance personality disorder, sexual dysfunction, eating disorders, obesity, drug dependence in mammals, preferably humans Syndrome, cluster headache, migraine, pain, Alzheimer's disease, obsessive compulsive disorder, panic disorder, memory disorder, Parkinson's disease, endocrine disorder, cerebellar ataxia, gastrointestinal disorders, negative symptoms of schizophrenia, premenstrual syndrome For treating a disease or condition selected from the group consisting of: fibromyalgia syndrome, stress urinary incontinence, Tourette syndrome, hair removal fistula, stealing, male dysfunction, cancer, chronic paroxysmal migraine and headache (i A) a corticotropin releasing factor antagonist or a pharmaceutically acceptable salt thereof; (ii) a compound of formula I as described in (A) and (B) a compound of formula II as described in the specification; 5-HT 1B receptor antagonist or a pharmaceutically acceptable salt thereof is selected from and to optionally (iii) a pharmaceutical composition comprising a pharmaceutically acceptable carrier. |