| abstract |
[Chemical 1] The present invention relates to pharmaceutically active quinoxalinones of formula (1), compositions containing them, and methods for making and using them [wherein R 1 is H, C 1-6 alkyl or halo. Yes; R 2 is H or halo; R 3 is H, C 1-6 alkyl, X is N or CH; Y is a covalent bond, —NHCO— or —CONH—; Z is phenyl Or a 5- or 6-membered heterocyclyl having 1 and 2 heteroatoms independently selected from N, O and S; and n is 0, 1 or 2; or a pharmaceutically acceptable salt thereof Characterized salts, esters, amides, hydrates or solvates] and their use as glycogen phosphorylase inhibitors for the treatment of diabetes and obesity. |