http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2007516201-A
Outgoing Links
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|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4184 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4178 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4184 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-422 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 |
| filingDate | 2004-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2007-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2007516201-A |
| titleOfInvention | Pharmaceutical compounds |
| abstract | The present invention provides a compound of formula (I): [wherein X is CR 5 or N; A is a bond or — (CH 2 ) m — (B) n —; B is C═O, NR g (C═O) or O (C═O), wherein R g is hydrogen or C 1-4 hydrocarbyl optionally substituted with hydroxy or C 1-4 alkoxy; m is 0, 1 or 2; n is 0 or 1; R 1 is hydrogen, a carbocyclic or heterocyclic group having 3 to 12 ring members, or optionally substituted. be also good C 1-8 hydrocarbyl group; R 2 is hydrogen, halogen, methoxy, or halogen, optionally be substituted C 1-4 hydrocarbyl group with a hydroxyl or methoxy; R 3 and R 4 Are the same or different, S, is selected from hydrogen, CN, C (O) R 8, optionally optionally substituted C 1-8 hydrocarbyl, and carbocyclic or heterocyclic groups having from 3 to 12 ring members; R 5 Is hydrogen, R 2 group or R 10 group, wherein R 10 is halogen, hydroxy, trifluoromethyl, cyano, nitro, carboxy, amino, mono- or di-C 1-4 hydrocarbylamino, 3 A carbocyclic group and a heterocyclic group having ~ 12 ring members, a R a -R b group, wherein R a is a bond, O, CO, X 1 C (X 2 ), C (X 2 ) X 1, X 1 C ( X 2) X 1, S, SO, be SO 2, NR c, SO 2 NR c or NR c SO 2; R b is hydrogen and the carbon bearing 3 to 12 ring members Cyclic and heterocyclic groups, and hydroxy, oxo, Androgenic, cyano, nitro, carboxy, amino, mono- - or di -C 1-4 hydrocarbylamino, with one or more substituents selected from carbocyclic and heterocyclic groups having from 3 to 12 ring members substituted are selected from optionally C 1-8 hydrocarbyl group, one or more carbon atoms of the C 1-8 hydrocarbyl group O, S, SO, SO 2 , NR c, X 1 C (X 2), Optionally substituted with C (X 2 ) X 1 or X 1 C (X 2 ) X 1 ; R c is selected from hydrogen and C 1-4 hydrocarbyl; X 1 is O, S or NR c , X 2 is ═O, ═S or ═NR c ; R 8 is selected from OR 11 , SR 11 and NR 12 R 13 ; R 11 is optionally substituted C 1-8 Hidoroka It is selected buildings, and the carbocyclic or heterocyclic group having 3 to 12 ring members; and one of R 12 and R 13 are R 11 group, the other of R 12 and R 13 are hydrogen or C 1-4 alkyl; or R 12 and R 13 together with the nitrogen atom to which they are attached have 4 to 7 ring members and are selected from N, O and S Forming a saturated heterocyclic group containing 1, 2 or 3 heteroatom ring members, or a salt, N-oxide or solvate thereof. These compounds have activity against cyclin dependent kinases, glycogen synthase kinases and aurora kinases. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2015535227-A |
| priorityDate | 2003-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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