http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2007515457-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-041 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H23-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0482 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-714 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H23-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-00 |
| filingDate | 2004-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2007-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2007515457-A |
| titleOfInvention | Cobalamin derivatives effective for diagnosis and treatment of abnormal cell proliferation |
| abstract | The present invention comprises (a) no or low binding affinity to the transport protein transcobalamin II (TCII), and (b) retains activity as a vitamin B12 substitute, optionally a therapeutic and / or diagnostic agent, For example, it relates to a cobalamin derivative carrying a radioactive metal. These compounds have a much lower rate of accumulation in blood and benign organs such as the kidney and liver than those in neoplastic tissue and are cleared more rapidly from the blood. The present invention further includes a novel in mammals comprising: (a) subjecting the mammal to a vitamin B12 deficient diet for a period of time; and (b) subsequently applying a cobalamin derivative of the invention carrying a diagnostic and / or therapeutic agent. The present invention relates to a method for diagnosing and treating biological diseases or infections caused by microorganisms. By selecting a cobalamin derivative that acts as a vitamin B12 substitute, the risk of forming resistant progeny in neoplastic tissue is greatly reduced. |
| priorityDate | 2003-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 208.