abstract |
The present invention relates generally to the field of ligands for nicotine acetylcholine receptor (nAChR), activation of nAChR, and treatment of brain pathological conditions associated with deficient or dysfunctional nicotine acetylcholine receptors. The present invention further provides novel compounds that act as ligands for the α7 nAChR subtype, such as indoles, 1H-indazoles, 1,2-benzisoxazoles and 1,2-benzisotisols, and the preparation of such compounds The present invention relates to methods, compositions containing such compounds, and methods of use thereof. |