| abstract |
The invention features rifamycin analogs that can be used as therapeutic agents for treating or preventing various bacterial infections. In one form, the analog is acetylated at position 25, similar to rifamycin. In another form, the analog is deacetylated at position 25. In yet other forms, the benzoxazino rifamycin, benzthiazino rifamycin and benzdiazino rifamycin analogs are benzene rings including 3'-hydroxy analogs, and / or 4 ', 5' positions, or 4 ' Various positions of various fused ring systems with a benzene ring at the 6 ′ position are derivatized. |