| abstract |
Stabilized containing interferon (IFN), or its isoform, mutein, fusion protein, functional derivative, active fraction, or salt, which is a solution containing buffer, cyclodextrin, isotonic agent and antioxidant. Liquid pharmaceutical compositions are described in the present invention. Preferably, the interferon is interferon β-1a and the cyclodextrin is HPBCD. The formulations of the present invention are stable at room temperature, thus providing the advantage of reducing the cost of storing the formulation and increasing patient safety with respect to possible “errors” during handling. Indeed, having such a formulation that is stable at room temperature reduces the risk of formation of degradation products potentially involved in adverse events (eg, immunogenicity). |