abstract |
[Chemical 1] The present invention relates to a group of hydronopol derivatives that are agonists to the human ORL1 (nociceptin) receptor. The present invention is for the preparation of these compounds, pharmaceutical compositions containing as active ingredient at least one pharmacologically active amount of these novel hydronopol derivatives, as well as for the treatment of disorders involving the ORL1 receptor. Also relates to the use of these pharmaceutical compositions. The present invention relates to compounds of general formula (1), in which the symbols have the meanings indicated in the description. |