| abstract |
An immunogenic composition comprising a recombinant protein, wherein the recombinant protein comprises Bordetella CyaA or a fragment thereof and a peptide corresponding to a tumor antigen is provided as a cancer treatment. Methods of treatment with this immunogenic composition are also provided. In certain embodiments, the therapeutic composition is a treatment for melanoma and comprises an epitope from the HLA * 0201 epitope. These epitopes include Tyr or GnT-V and are present in the recombinant proteins CyaA-E5-Tyr and CyaA-E5-GnT-V. |